This activation of JNK is dependent on IRE1 and TRAF2 and

Here we show that activation of JNK in the ER stress response precedes activation of XBP1. This activation of JNK is dependent on IRE1 and TRAF2 and coincides with JNK dependent induction of expression of several antiapoptotic genes, including cIAP1 steroids, cIAP2 steroids, XIAP, and BIRC6. ER stressed jnk1/ jnk2/ mouse embryonic fibroblasts (MEFs) display […]

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